Effect of Sulfaphenazole on Tissue Plasminogen Activator Release in Normotensive Subjects and Hypertensive Patients | Zendy

Chiara Giannarelli | Zendy; Agostino Virdis | Zendy; Ferdinando De Negri | Zendy; Armando Magagna | Zendy; Emiliano Duranti | Zendy; Antonio Salvetti | Zendy; Stefano Taddei | Zendy

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Effect of Sulfaphenazole on Tissue Plasminogen Activator Release in Normotensive Subjects and Hypertensive Patients

Author(s) -

Chiara Giannarelli,

Agostino Virdis,

Ferdinando De Negri,

Armando Magagna,

Emiliano Duranti,

Antonio Salvetti,

Stefano Taddei

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.782482

Subject(s) - bradykinin , medicine , acetylcholine , endocrinology , tissue plasminogen activator , nitric oxide , fibrinolysis , pharmacology , vasodilation , plasminogen activator , receptor

A nitric oxide-independent response, possibly mediated by hyperpolarization, regulates vascular tone, acting as a compensatory mechanism in the presence of impaired nitric oxide availability. Cytochrome P450 2C9 (CYP 2C9) is a source of endothelium-derived hyperpolarizing factors and modulates tissue-type plasminogen activator (tPA) release from endothelial cells; however, no effect of hyperpolarization on fibrinolysis has been documented in humans. We aimed to assess the effect of sulfaphenazole, a specific CYP 2C9 inhibitor, on tPA release in normotensive subjects and patients with essential hypertension.

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