A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension | Zendy

Ying Yu | Zendy; Steve H. Keller | Zendy; Carmelle V. Remillard | Zendy; Olga Safrina | Zendy; Ann E. Nicholson | Zendy; Shenyuan L. Zhang | Zendy; Weihua Jiang | Zendy; Nivruthi Vangala | Zendy; Judd W. Landsberg | Zendy; Jian-Ying Wang | Zendy; Patricia A. Thistlethwaite | Zendy; Richard N. Channick | Zendy; Ivan M. Robbins | Zendy; James E. Loyd | Zendy; Hossein A. Ghofrani | Zendy; Friedrich Grimminger | Zendy; Ralph T. Schermuly | Zendy; Michael D. Cahalan | Zendy; Lewis J. Rubin | Zendy; Jason X.J. Yuan | Zendy

Open Access

A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

Author(s) -

Ying Yu,

Steve H. Keller,

Carmelle V. Remillard,

Olga Safrina,

Ann E. Nicholson,

Shenyuan L. Zhang,

Weihua Jiang,

Nivruthi Vangala,

Judd W. Landsberg,

Jian-Ying Wang,

Patricia A. Thistlethwaite,

Richard N. Channick,

Ivan M. Robbins,

James E. Loyd,

Hossein A. Ghofrani,

Friedrich Grimminger,

Ralph T. Schermuly,

Michael D. Cahalan,

Lewis J. Rubin,

Jason X.J. Yuan

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.782458

Subject(s) - single nucleotide polymorphism , snp , allele , trpc6 , downregulation and upregulation , medicine , endocrinology , genotype , microbiology and biotechnology , gene , biology , genetics , receptor , transient receptor potential channel

Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role in the development of idiopathic pulmonary arterial hypertension (IPAH), whereas a rise in cytosolic Ca2+ concentration triggers PASMC contraction and stimulates PASMC proliferation. Recently, we demonstrated that upregulation of the TRPC6 channel contributes to proliferation of PASMCs isolated from IPAH patients. This study sought to identify single-nucleotide polymorphisms (SNPs) in the TRPC6 gene promoter that are associated with IPAH and have functional significance in regulating TRPC6 activity in PASMCs.

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