Activation of Liver X Receptors Promotes Neuroprotection and Reduces Brain Inflammation in Experimental Stroke | Zendy

Jesús R Morales | Zendy; Iván Ballesteros | Zendy; José Manuel Deniz | Zendy; Olivia Hurtado | Zendy; José Vivancos | Zendy; Florentino Nombela | Zendy; Ignacio Lizasoaín | Zendy; Antonio Castrillo | Zendy; Marı́a A. Moro | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Activation of Liver X Receptors Promotes Neuroprotection and Reduces Brain Inflammation in Experimental Stroke

Author(s) -

Jesús R Morales,

Iván Ballesteros,

José Manuel Deniz,

Olivia Hurtado,

José Vivancos,

Florentino Nombela,

Ignacio Lizasoaín,

Antonio Castrillo,

Marı́a A. Moro

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.782300

Subject(s) - liver x receptor , neuroprotection , inflammation , medicine , nuclear receptor , pharmacology , stroke (engine) , proinflammatory cytokine , receptor , endocrinology , biology , transcription factor , biochemistry , mechanical engineering , engineering , gene

The liver X receptors (LXRs) belong to the nuclear receptor superfamily and act as transcriptional regulators of cholesterol metabolism in several tissues. Recent work also has identified LXRs as potent antiinflammatory molecules in macrophages and other immune cells. Combined changes in lipid and inflammatory profiles are likely mediating the protective role of LXRs in models of chronic injury like atherosclerosis. These beneficial actions, however, have not been illustrated in other models of acute injury such as stroke in which inflammation is an important pathophysiological feature.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research