Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis | Zendy

Naritaka Kimura | Zendy; Chisa Shukunami | Zendy; Daihiko Hakuno | Zendy; Masatoyo Yoshioka | Zendy; Shigenori Miura | Zendy; Denitsa Docheva | Zendy; Takehiro Kimura | Zendy; Yasunori Okada | Zendy; Goki Matsumura | Zendy; Toshiharu Shinoka | Zendy; Ryohei Yozu | Zendy; Junjiro Kobayashi | Zendy; Hatsue IshibashiUeda | Zendy; Yuji Hiraki | Zendy; Keiichi Fukuda | Zendy

Open Access

Local Tenomodulin Absence, Angiogenesis, and Matrix Metalloproteinase Activation Are Associated With the Rupture of the Chordae Tendineae Cordis

Author(s) -

Naritaka Kimura,

Chisa Shukunami,

Daihiko Hakuno,

Masatoyo Yoshioka,

Shigenori Miura,

Denitsa Docheva,

Takehiro Kimura,

Yasunori Okada,

Goki Matsumura,

Toshiharu Shinoka,

Ryohei Yozu,

Junjiro Kobayashi,

Hatsue IshibashiUeda,

Yuji Hiraki,

Keiichi Fukuda

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.780031

Subject(s) - medicine , angiogenesis , matrix metalloproteinase , vascular endothelial growth factor , pathology , anatomy , vegf receptors

Rupture of the chordae tendineae cordis (CTC) is a well-known cause of mitral regurgitation. Despite its importance, the mechanisms by which the CTC is protected and the cause of its rupture remain unknown. CTC is an avascular tissue. We investigated the molecular mechanisms underlying the avascularity of CTC and the correlation between avascularity and CTC rupture.

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