Advanced Glycation End Products Accumulate in Vascular Smooth Muscle and Modify Vascular but Not Ventricular Properties in Elderly Hypertensive Canines | Zendy

Brian P. Shapiro | Zendy; Theophilus Owan | Zendy; Selma F. Mohammed | Zendy; Donna Meyer | Zendy; Lisa Mills | Zendy; Casper G. Schalkwijk | Zendy; Margaret M. Redfield | Zendy

Open Access

Advanced Glycation End Products Accumulate in Vascular Smooth Muscle and Modify Vascular but Not Ventricular Properties in Elderly Hypertensive Canines

Author(s) -

Brian P. Shapiro,

Theophilus Owan,

Selma F. Mohammed,

Donna Meyer,

Lisa Mills,

Casper G. Schalkwijk,

Margaret M. Redfield

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.777326

Subject(s) - medicine , cardiology , glycation , blood pressure , vascular resistance , pulse pressure , compliance (psychology) , aorta , vascular smooth muscle , elastin , pathology , psychology , social psychology , receptor , smooth muscle

Advanced glycation end products (AGEs) are believed to increase left ventricular (LV) and vascular stiffness, in part via cross-linking proteins. We determined whether and where AGEs were increased in elderly hypertensive nondiabetic dogs and whether an AGE cross-link breaker (ALT-711) improved vascular or ventricular function.

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