Dose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose | Zendy

JeanPhilippe Collet | Zendy; Johanne Silvain | Zendy; Antoine Landivier | Zendy; MarieLaure Tanguy | Zendy; Guillaume Cayla | Zendy; Anne Bellemain | Zendy; Nicolas Vignolles | Zendy; Sophie Gallier | Zendy; Farzin Beygui | Zendy; Ana Peña | Zendy; Gilles Montalescot | Zendy

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Dose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose

Author(s) -

JeanPhilippe Collet,

Johanne Silvain,

Antoine Landivier,

MarieLaure Tanguy,

Guillaume Cayla,

Anne Bellemain,

Nicolas Vignolles,

Sophie Gallier,

Farzin Beygui,

Ana Peña,

Gilles Montalescot

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.776757

Subject(s) - clopidogrel , medicine , loading dose , maintenance dose , percutaneous coronary intervention , acute coronary syndrome , platelet , coronary artery disease , dose , cardiology , anesthesia , myocardial infarction

Clopidogrel loading has mostly been studied in clopidogrel-naïve patients. Whether clopidogrel-treated patients readmitted for an acute coronary syndrome or percutaneous coronary intervention can benefit from a new load of clopidogrel and at what dose remain unknown. Our aim was to evaluate the impact of 3 different strategies of administration of a loading dose of 900 mg clopidogrel in patients already treated with a maintenance dose of 75 mg clopidogrel for at least 7 days on residual platelet aggregation.

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