Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography | Zendy

Christie M. Ballantyne | Zendy; Joel S. Raichlen | Zendy; Stephen J. Nicholls | Zendy; Raimund Erbel | Zendy; JeanClaude Tardif | Zendy; Sorin J. Brener | Zendy; Valerie A. Cain | Zendy; Steven E. Nissen | Zendy

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Effect of Rosuvastatin Therapy on Coronary Artery Stenoses Assessed by Quantitative Coronary Angiography

Author(s) -

Christie M. Ballantyne,

Joel S. Raichlen,

Stephen J. Nicholls,

Raimund Erbel,

JeanClaude Tardif,

Sorin J. Brener,

Valerie A. Cain,

Steven E. Nissen

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.773747

Subject(s) - medicine , rosuvastatin , intravascular ultrasound , stenosis , cardiology , coronary artery disease , atheroma , lumen (anatomy) , angiography , artery , radiology , coronary atherosclerosis , statin

Previous studies using quantitative coronary angiography have demonstrated that statin therapy slows the progression of coronary stenoses in proportion to average low-density lipoprotein cholesterol levels during therapy. However, no major statin monotherapy study has demonstrated either halted progression or regression of angiographic disease. A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID) assessed whether rosuvastatin could regress coronary atherosclerosis by intravascular ultrasound and quantitative coronary angiography. Intravascular ultrasound showed atheroma volume regression in a single coronary artery with <50% angiographic luminal narrowing.

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