Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function | Zendy

Amy D. Bradshaw | Zendy; Catalin F. Baicu | Zendy; Tyler J. Rentz | Zendy; An O. Van Laer | Zendy; Janet M. Boggs | Zendy; J. Matthew Lacy | Zendy; Michael R. Zile | Zendy

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Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function

Author(s) -

Amy D. Bradshaw,

Catalin F. Baicu,

Tyler J. Rentz,

An O. Van Laer,

Janet M. Boggs,

J. Matthew Lacy,

Michael R. Zile

Publication year - 2009

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.773424

Subject(s) - hydroxyproline , pressure overload , medicine , extracellular matrix , muscle hypertrophy , procollagen peptidase , endocrinology , diastolic function , cardiac function curve , diastole , type i collagen , heart failure , cardiac hypertrophy , chemistry , biochemistry , blood pressure

Chronic pressure overload causes myocardial hypertrophy, increased fibrillar collagen content, and abnormal diastolic function. We hypothesized that one determinant of these pressure overload-induced changes is the extracellular processing of newly synthesized procollagen into mature collagen fibrils. We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen processing in normal and pressure-overloaded myocardium.

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