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Ventricular arrhythmias are life-threatening complications of heart failure and myocardial ischemia. Increased diastolic Ca2+ overload occurring in ischemia leads to afterdepolarizations and aftercontractions that are responsible for cellular electric instability. We inquired whether sarcoplasmic reticulum Ca2+ ATPase pump (SERCA2a) overexpression could reduce ischemic ventricular arrhythmias by modulating Ca2+ overload.

circulation

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca <sup>2+</sup> ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca 2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca ²⁺ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion