Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca 2+ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion | Zendy

Fabrice Prunier | Zendy; Yoshiaki Kawase | Zendy; Davide Gianni | Zendy; Cristina Scapin | Zendy; Stephan B. Danik | Zendy; Patrick T. Ellinor | Zendy; Roger J. Hajjar | Zendy; Federica del Monte | Zendy

Open Access

Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca ²⁺ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

Author(s) -

Fabrice Prunier,

Yoshiaki Kawase,

Davide Gianni,

Cristina Scapin,

Stephan B. Danik,

Patrick T. Ellinor,

Roger J. Hajjar,

Federica del Monte

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.770883

Subject(s) - medicine , endoplasmic reticulum , ischemia , cardiology , atpase , microbiology and biotechnology , nuclear magnetic resonance , enzyme , physics , biology

Ventricular arrhythmias are life-threatening complications of heart failure and myocardial ischemia. Increased diastolic Ca2+ overload occurring in ischemia leads to afterdepolarizations and aftercontractions that are responsible for cellular electric instability. We inquired whether sarcoplasmic reticulum Ca2+ ATPase pump (SERCA2a) overexpression could reduce ischemic ventricular arrhythmias by modulating Ca2+ overload.

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