Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling | Zendy

Paula A. da Costa Martins | Zendy; Meriem Bourajjaj | Zendy; Monika M Gladka | Zendy; Mara Kortland | Zendy; Ralph J. van Oort | Zendy; Yigal M. Pinto | Zendy; Jeffery D. Molkentin | Zendy; León J. De Windt | Zendy

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Conditional Dicer Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling

Author(s) -

Paula A. da Costa Martins,

Meriem Bourajjaj,

Monika M Gladka,

Mara Kortland,

Ralph J. van Oort,

Yigal M. Pinto,

Jeffery D. Molkentin,

León J. De Windt

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.769984

Subject(s) - dicer , microrna , cre recombinase , conditional gene knockout , medicine , biology , microbiology and biotechnology , gene silencing , small interfering rna , cancer research , gene , genetics , phenotype , transgene , rna , genetically modified mouse

Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs) into mature 22-nucleotide miRNAs, has proven a useful target to dissect the significance of miRNAs biogenesis in mammalian biology.

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