Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs | Zendy

GuiRong Li | Zendy; Hongbing Wang | Zendy; GuoWei Qin | Zendy; ManWen Jin | Zendy; Qiang Tang | Zendy; HaiYing Sun | Zendy; Xinling Du | Zendy; XiuLing Deng | Zendy; Xiaohua Zhang | Zendy; Jingbo Chen | Zendy; Lei Chen | Zendy; Xiaohui Xu | Zendy; LikCheung Cheng | Zendy; ShuiWah Chiu | Zendy; HungFat Tse | Zendy; Paul M. Vanhoutte | Zendy; ChuPak Lau | Zendy

Open Access

Acacetin, a Natural Flavone, Selectively Inhibits Human Atrial Repolarization Potassium Currents and Prevents Atrial Fibrillation in Dogs

Author(s) -

GuiRong Li,

Hongbing Wang,

GuoWei Qin,

ManWen Jin,

Qiang Tang,

HaiYing Sun,

Xinling Du,

XiuLing Deng,

Xiaohua Zhang,

Jingbo Chen,

Lei Chen,

Xiaohui Xu,

LikCheung Cheng,

ShuiWah Chiu,

HungFat Tse,

Paul M. Vanhoutte,

ChuPak Lau

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.769554

Subject(s) - acacetin , medicine , atrial fibrillation , effective refractory period , pharmacology , qt interval , cardiology , herg , atrium (architecture) , potassium channel , chemistry , flavonoid , biochemistry , apigenin , antioxidant

The development of atrium-selective antiarrhythmic agents is a current strategy for inhibiting atrial fibrillation (AF). The present study investigated whether the natural flavone acacetin from the traditional Chinese medicine Xuelianhua would be an atrium-selective anti-AF agent.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research