Follistatin-Like 1 Is an Akt-Regulated Cardioprotective Factor That Is Secreted by the Heart | Zendy

Yuichi Oshima | Zendy; Noriyuki Ouchi | Zendy; Kaori Sato | Zendy; Yasuhiro Izumiya | Zendy; David R. Pimentel | Zendy; Kenneth Walsh | Zendy

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Follistatin-Like 1 Is an Akt-Regulated Cardioprotective Factor That Is Secreted by the Heart

Author(s) -

Yuichi Oshima,

Noriyuki Ouchi,

Kaori Sato,

Yasuhiro Izumiya,

David R. Pimentel,

Kenneth Walsh

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.108.767673

Subject(s) - protein kinase b , medicine , myocyte , autocrine signalling , downregulation and upregulation , follistatin , cardioprotection , paracrine signalling , endocrinology , akt1 , apoptosis , cardiac myocyte , signal transduction , myocardial infarction , microbiology and biotechnology , biology , receptor , biochemistry , gene

The Akt protein kinase is an important mediator of cardiac myocyte growth and survival. To identify factors with novel therapeutic applications in cardiac diseases, we focused on the identification of factors secreted from Akt1-activated cells that have cardioprotective effects through autocrine/paracrine mechanisms.

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