A Factor Underlying Late-Phase Arrhythmogenicity After Cell Therapy to the Heart | Zendy

Steven R. Coppen | Zendy; Satsuki Fukushima | Zendy; Yasunori Shintani | Zendy; Kunihiko Takahashi | Zendy; Anabel VarelaCarver | Zendy; Husein K. Salem | Zendy; Kenta Yashiro | Zendy; Magdi H. Yacoub | Zendy; Ken Suzuki | Zendy

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A Factor Underlying Late-Phase Arrhythmogenicity After Cell Therapy to the Heart

Author(s) -

Steven R. Coppen,

Satsuki Fukushima,

Yasunori Shintani,

Kunihiko Takahashi,

Anabel VarelaCarver,

Husein K. Salem,

Kenta Yashiro,

Magdi H. Yacoub,

Ken Suzuki

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.779629

Subject(s) - medicine , ejection fraction , heart failure , cardiology , downregulation and upregulation , ventricular tachycardia , cell , endocrinology , biology , gene , biochemistry , genetics

Arrhythmia occurrence is a variable but serious concern of cell therapy for treating heart failure. Using a rat postinfarction chronic heart failure model, we compared skeletal myoblast (SMB) with bone marrow cell (BMC) injection to highlight donor cell-specific, late-phase arrhythmogenesis and the underlying factors.

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