Platelet P2Y 12 Receptor Influences the Vessel Wall Response to Arterial Injury and Thrombosis | Zendy

David Evans | Zendy; Laura E. Jackman | Zendy; Janet Chamberlain | Zendy; Daniel J. Crosdale | Zendy; Heather M. Judge | Zendy; Karim Jetha | Zendy; Keith E. Norman | Zendy; Sheila E. Francis | Zendy; Robert F. Storey | Zendy

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Platelet P2Y ₁₂ Receptor Influences the Vessel Wall Response to Arterial Injury and Thrombosis

Author(s) -

David Evans,

Laura E. Jackman,

Janet Chamberlain,

Daniel J. Crosdale,

Heather M. Judge,

Karim Jetha,

Keith E. Norman,

Sheila E. Francis,

Robert F. Storey

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.762690

Subject(s) - platelet , medicine , neointima , thrombosis , platelet activation , transplantation , pathology , endocrinology , restenosis , stent

Platelets are believed to play an important role in atherogenesis and the vessel response to vascular injury. The P2Y(12) receptor (P2Y(12)) plays a central role in amplifying platelet aggregation, dense granule and alpha-granule secretion, P-selectin expression, microparticle formation, and procoagulant membrane changes, regardless of the activating stimulus. We hypothesized that P2Y(12) deficiency might reduce the vessel wall response to vascular injury as well as thrombosis in murine vascular injury models.

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