Suppression of c-Cbl Tyrosine Phosphorylation Inhibits Neointimal Formation in Balloon-Injured Rat Arteries | Zendy

Zhihui Tang | Zendy; Ying Wang | Zendy; Yanbo Fan | Zendy; Yi Zhu | Zendy; Shu Chien | Zendy; Nanping Wang | Zendy

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Suppression of c-Cbl Tyrosine Phosphorylation Inhibits Neointimal Formation in Balloon-Injured Rat Arteries

Author(s) -

Zhihui Tang,

Ying Wang,

Yanbo Fan,

Yi Zhu,

Shu Chien,

Nanping Wang

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.761932

Subject(s) - phosphorylation , platelet derived growth factor receptor , tyrosine phosphorylation , protein kinase b , vascular smooth muscle , pi3k/akt/mtor pathway , platelet derived growth factor , microbiology and biotechnology , tyrosine , growth factor , medicine , signal transduction , cancer research , endocrinology , biology , biochemistry , receptor , smooth muscle

c-Cbl, a ubiquitously expressed protooncogene, is tyrosine phosphorylated in response to a variety of stimuli, including growth factors such as platelet-derived growth factor (PDGF), and consequently activates signaling proteins such as phosphatidylinositol-3 kinase (PI3K) and Akt. In the present study, we examined the role of c-Cbl tyrosine phosphorylation in vascular injury.

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