Short Hairpin RNA Interference Therapy for Ischemic Heart Disease | Zendy

Mei Huang | Zendy; Denise A. Chan | Zendy; Fangjun Jia | Zendy; Xiaoyan Xie | Zendy; Zongjin Li | Zendy; Grant Hoyt | Zendy; Robert C. Robbins | Zendy; Xiaohong Chen | Zendy; Amato J. Giaccia | Zendy; Joseph C. Wu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Short Hairpin RNA Interference Therapy for Ischemic Heart Disease

Author(s) -

Mei Huang,

Denise A. Chan,

Fangjun Jia,

Xiaoyan Xie,

Zongjin Li,

Grant Hoyt,

Robert C. Robbins,

Xiaohong Chen,

Amato J. Giaccia,

Joseph C. Wu

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.760785

Subject(s) - small hairpin rna , microbiology and biotechnology , genetic enhancement , transfection , medicine , rna interference , gene silencing , myocyte , adeno associated virus , rna , gene , biology , recombinant dna , biochemistry , vector (molecular biology)

During hypoxia, upregulation of hypoxia inducible factor-1 alpha transcriptional factor can activate several downstream angiogenic genes. However, hypoxia inducible factor-1 alpha is naturally degraded by prolyl hydroxylase-2 (PHD2) protein. Here we hypothesize that short hairpin RNA (shRNA) interference therapy targeting PHD2 can be used for treatment of myocardial ischemia and this process can be followed noninvasively by molecular imaging.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research