Quantitative Control of Adaptive Cardiac Hypertrophy by Acetyltransferase p300
Author(s) -
Jian Wei,
Lina A. Shehadeh,
James Mitrani,
Mônica Gomes Pessanha,
Tatiana I. Slepak,
Keith A. Webster,
Nanette H. Bishopric
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.760488
Subject(s) - mef2 , pressure overload , histone acetyltransferase , muscle hypertrophy , medicine , gata4 , hdac4 , heart failure , acetylation , acetyltransferase , histone deacetylase 5 , histone deacetylase , ventricular remodeling , endocrinology , histone , transcription factor , microbiology and biotechnology , biology , enhancer , biochemistry , gene , cardiac hypertrophy
Acetyltransferase p300 is essential for cardiac development and is thought to be involved in cardiac myocyte growth through MEF2- and GATA4-dependent transcription. However, the importance of p300 in the modulation of cardiac growth in vivo is unknown.
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