Functionally Opposing Roles of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in the Regulation of Cardiac Contractility | Zendy

István Szokodi | Zendy; Risto Kerkelä | Zendy; AnnaMaria Kubin | Zendy; Balázs Sármán | Zendy; Sampsa Pikkarainen | Zendy; Attila Kónyi | Zendy; Iván Horváth | Zendy; Lajos Papp | Zendy; Miklós Tóth | Zendy; Réka Skoumal | Zendy; Heikki Ruskoaho | Zendy

Open Access

Functionally Opposing Roles of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in the Regulation of Cardiac Contractility

Author(s) -

István Szokodi,

Risto Kerkelä,

AnnaMaria Kubin,

Balázs Sármán,

Sampsa Pikkarainen,

Attila Kónyi,

Iván Horváth,

Lajos Papp,

Miklós Tóth,

Réka Skoumal,

Heikki Ruskoaho

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.758623

Subject(s) - contractility , mapk/erk pathway , protein kinase a , kinase , p38 mitogen activated protein kinases , phospholamban , microbiology and biotechnology , phosphorylation , signal transduction , ribosomal s6 kinase , endocrinology , medicine , biology , protein kinase b , p70 s6 kinase 1

Extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38-MAPK) have been shown to regulate various cellular processes, including cell growth, proliferation, and apoptosis in the heart. However, the function of these signaling pathways in the control of cardiac contractility is unclear. Here, we characterized the contribution of ERK1/2 and p38-MAPK to the inotropic effect of endothelin-1 (ET-1).

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