Hypoxia-Inducible Factor-1 Is Central to Cardioprotection | Zendy

Tobias Eckle | Zendy; D. Köhler | Zendy; Rainer Lehmann | Zendy; Karim C. El Kasmi | Zendy; Holger K. Eltzschig | Zendy

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Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

Author(s) -

Tobias Eckle,

D. Köhler,

Rainer Lehmann,

Karim C. El Kasmi,

Holger K. Eltzschig

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.758516

Subject(s) - cardioprotection , ischemic preconditioning , medicine , hypoxia (environmental) , pharmacology , ischemia , activator (genetics) , hypoxia inducible factors , receptor , biology , chemistry , biochemistry , oxygen , organic chemistry , gene

Ischemic preconditioning provides strong cardioprotection from ischemia, but its molecular mechanisms remain unknown. Convincing evidence confirms a central role of hypoxia-inducible factor (HIF)-1 in mammalian oxygen homeostasis. Thus, we pursued HIF-1 as a central component of cardioprotection by ischemic preconditioning.

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