Open AccessCardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation
Author(s) -
Dawood Darbar,
Prince J. Kannankeril,
Brian S. Donahue,
Gayle Kucera,
Tanya Stubblefield,
Jonathan L. Haines,
Alfred L. George,
Dan M. Roden
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.757955
Subject(s) - medicine , atrial fibrillation , sodium channel , cardiology , cardiac arrhythmia , sodium , chemistry , organic chemistry
Genetic studies have identified ion channel gene variants in families segregating atrial fibrillation (AF), the most common arrhythmia in clinical practice. Here, we tested the hypothesis that vulnerability to AF is associated with variation in SCN5A, the gene encoding the cardiac sodium channel.
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