Progesterone Induces Human Leukocyte Antigen-G Expression in Vascular Endothelial and Smooth Muscle Cells | Zendy

Rohit Sheshgiri | Zendy; Vivek Rao | Zendy; Laura C. Tumiati | Zendy; Rong Xiao | Zendy; Jessica L. Prodger | Zendy; Mitesh Badiwala | Zendy; Clifford Librach | Zendy; Diego Delgado | Zendy

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Progesterone Induces Human Leukocyte Antigen-G Expression in Vascular Endothelial and Smooth Muscle Cells

Author(s) -

Rohit Sheshgiri,

Vivek Rao,

Laura C. Tumiati,

Rong Xiao,

Jessica L. Prodger,

Mitesh Badiwala,

Clifford Librach,

Diego Delgado

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.757781

Subject(s) - medicine , vascular smooth muscle , endothelial stem cell , hypoxia (environmental) , endocrinology , immunology , biology , smooth muscle , chemistry , in vitro , biochemistry , organic chemistry , oxygen

Human leukocyte antigen-G (HLA-G) expression in heart transplant patients has been negatively associated with acute cellular rejection and cardiac allograft vasculopathy. We assessed HLA-G expression in vascular human endothelial and smooth muscle cell cultures to determine if future therapeutic agents can be targeted toward inducing HLA-G expression to protect against allograft rejection and vasculopathy.

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