Modulated Inflammation by Injection of High-Mobility Group Box 1 Recovers Post-Infarction Chronically Failing Heart | Zendy

Kunihiko Takahashi | Zendy; Satsuki Fukushima | Zendy; Kenichi Yamahara | Zendy; Kenta Yashiro | Zendy; Yasunori Shintani | Zendy; Steven R. Coppen | Zendy; Husein K. Salem | Zendy; Scott Brouilette | Zendy; Magdi H. Yacoub | Zendy; Ken Suzuki | Zendy

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Modulated Inflammation by Injection of High-Mobility Group Box 1 Recovers Post-Infarction Chronically Failing Heart

Author(s) -

Kunihiko Takahashi,

Satsuki Fukushima,

Kenichi Yamahara,

Kenta Yashiro,

Yasunori Shintani,

Steven R. Coppen,

Husein K. Salem,

Scott Brouilette,

Magdi H. Yacoub,

Ken Suzuki

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.757443

Subject(s) - medicine , hmgb1 , inflammation , fibrosis , ventricular remodeling , ejection fraction , cardiac fibrosis , proinflammatory cytokine , myocardial infarction , heart failure , cardiology

Inflammation plays an important role in the progress of adverse ventricular remodeling after myocardial infarction. High-mobility group box 1 (HMGB1) is a nuclear protein, which has recently been uncovered to also act as a modifier of inflammation when released. We hypothesized that HMGB1 injection could preferentially modulate local myocardial inflammation, attenuate ventricular remodeling, and subsequently improve cardiac performance of postinfarction chronic heart failure.

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