Open AccessMitochondrial Haplogroups
Author(s) -
Marianne Benn,
Marianne Schwartz,
Børge G. Nordestgaard,
Anne TybjærgHansen
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.756809
Subject(s) - medicine , haplogroup , hazard ratio , confidence interval , population , disease , haplotype , gastroenterology , allele , genetics , biology , environmental health , gene
Rare mutations in the mitochondrial genome may cause disease. Mitochondrial haplogroups defined by common polymorphisms have been associated with risk of disease and longevity. We tested the hypothesis that common haplogroups predict risk of ischemic cardiovascular disease, morbidity from other causes, mortality, and longevity in a general population of European descent.
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