A Novel Approach for Reducing Ischemic Mitral Regurgitation by Injection of a Polymer to Reverse Remodel and Reposition Displaced Papillary Muscles | Zendy

Judy Hung | Zendy; Jorge Solı́s | Zendy; Jorge Guerrero | Zendy; Gavin Braithwaite | Zendy; Orhun K. Muratoglu | Zendy; Miguel Chaput | Zendy; Leticia FernándezFriera | Zendy; Mark D. Handschumacher | Zendy; Van J. Wedeen | Zendy; Stuart L. Houser | Zendy; Gus J. Vlahakes | Zendy; Robert A. Levine | Zendy

Open Access

A Novel Approach for Reducing Ischemic Mitral Regurgitation by Injection of a Polymer to Reverse Remodel and Reposition Displaced Papillary Muscles

Author(s) -

Judy Hung,

Jorge Solı́s,

Jorge Guerrero,

Gavin Braithwaite,

Orhun K. Muratoglu,

Miguel Chaput,

Leticia FernándezFriera,

Mark D. Handschumacher,

Van J. Wedeen,

Stuart L. Houser,

Gus J. Vlahakes,

Robert A. Levine

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.756502

Subject(s) - medicine , vena contracta , papillary muscle , cardiology , ejection fraction , mitral regurgitation , ligation , heart failure

Ischemic mitral regurgitation (MR) relates to displacement of the papillary muscles from ischemic ventricular distortion. We tested the hypothesis that repositioning of the papillary muscles can be achieved by injection of polyvinyl-alcohol (PVA) polymer, a biologically inert biomaterial that has been specially formulated to produce an encapsulated, stable, resilient gel once injected into the myocardium. The purpose is to materially support the infarcted myocardium while at the same time repositioning the papillary muscles that become apically tethered in MR.

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