Contribution of Macromolecular Structure to the Retention of Low-Density Lipoprotein at Arterial Branch Points | Zendy

Gina P. Kwon | Zendy; Jamie Schroeder | Zendy; Marcelo Amar | Zendy; Alan T. Remaley | Zendy; Robert S. Balaban | Zendy

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Contribution of Macromolecular Structure to the Retention of Low-Density Lipoprotein at Arterial Branch Points

Author(s) -

Gina P. Kwon,

Jamie Schroeder,

Marcelo Amar,

Alan T. Remaley,

Robert S. Balaban

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.754614

Subject(s) - elastin , arterial wall , extracellular matrix , biophysics , proteoglycan , microstructure , lipoprotein , internal elastic lamina , anatomy , medicine , materials science , biochemistry , pathology , artery , chemistry , biology , cholesterol , composite material

Extracellular deposition of low-density lipoprotein (LDL) in the arterial wall is an essential early step in atherosclerosis. This process preferentially occurs at arterial branch points, reflecting a regional variation in lipoprotein-arterial wall interactions. In this study, we characterized the submicron microstructure of arterial wall collagen and elastin to evaluate its potential role in regional LDL deposition.

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