Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis | Zendy

Constantin von zur Mühlen | Zendy; Dominik von Elverfeldt | Zendy; J.A. Moeller | Zendy; Robin P. Choudhury | Zendy; Dominik Paul | Zendy; Christoph E. Hagemeyer | Zendy; Manfred Olschewski | Zendy; A E Becker | Zendy; Irene Neudorfer | Zendy; Nicole Bassler | Zendy; M. Schwarz | Zendy; Christoph Bode | Zendy; Karlheinz Peter | Zendy

Open Access

Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis

Author(s) -

Constantin von zur Mühlen,

Dominik von Elverfeldt,

J.A. Moeller,

Robin P. Choudhury,

Dominik Paul,

Christoph E. Hagemeyer,

Manfred Olschewski,

A E Becker,

Irene Neudorfer,

Nicole Bassler,

M. Schwarz,

Christoph Bode,

Karlheinz Peter

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.753657

Subject(s) - medicine , ex vivo , in vivo , thrombus , platelet activation , magnetic resonance imaging , platelet , thrombolysis , biomedical engineering , pathology , radiology , biology , microbiology and biotechnology , myocardial infarction

Platelets are the key to thrombus formation and play a role in the development of atherosclerosis. Noninvasive imaging of activated platelets would be of great clinical interest. Here, we evaluate the ability of a magnetic resonance imaging (MRI) contrast agent consisting of microparticles of iron oxide (MPIOs) and a single-chain antibody targeting ligand-induced binding sites (LIBS) on activated glycoprotein IIb/IIIa to image carotid artery thrombi and atherosclerotic plaques.

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