CCR2-Mediated Antiinflammatory Effects of Endothelial Tetrahydrobiopterin Inhibit Vascular Injury-Induced Accelerated Atherosclerosis | Zendy

Ziad A. Ali | Zendy; Christina A. Bursill | Zendy; Gillian Douglas | Zendy; Eileen McNeill | Zendy; Marianna Papaspyridonos | Zendy; Amy L. Tatham | Zendy; Jennifer K. Bendall | Zendy; Asim M. Akhtar | Zendy; Nicholas J. C. King | Zendy; David R. Greaves | Zendy; Keith M. Chan | Zendy

Open Access

CCR2-Mediated Antiinflammatory Effects of Endothelial Tetrahydrobiopterin Inhibit Vascular Injury-Induced Accelerated Atherosclerosis

Author(s) -

Ziad A. Ali,

Christina A. Bursill,

Gillian Douglas,

Eileen McNeill,

Marianna Papaspyridonos,

Amy L. Tatham,

Jennifer K. Bendall,

Asim M. Akhtar,

Nicholas J. C. King,

David R. Greaves,

Keith M. Chan

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.753558

Subject(s) - medicine , tetrahydrobiopterin , endothelial dysfunction , pharmacology , nitric oxide , nitric oxide synthase

Vascular injury results in loss of endothelial nitric oxide (NO), production of reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and ROS modulate inflammation through redox-sensitive pathways. Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) that regulates enzymatic synthesis of either nitric oxide or ROS. We hypothesized that endothelial BH4 is an important regulator of inflammation and vascular remodeling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research