Open AccessCardiomyocyte Expression of a Polyglutamine Preamyloid Oligomer Causes Heart Failure
Author(s) -
J. Scott Pattison,
Atsushi Sanbe,
Alina Maloyan,
Hanna Osińska,
Raisa Klevitsky,
Jeffrey Robbins
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.750232
Subject(s) - heart failure , medicine , genetically modified mouse , intracellular , neurotoxicity , microbiology and biotechnology , transgene , toxicity , biology , biochemistry , gene
To determine whether soluble preamyloid oligomers (PAOs) are toxic when expressed internally in the cardiomyocyte, we tested the hypothesis that cardiomyocyte-restricted expression and accumulation of a known PAO is cytotoxic and sufficient to cause heart failure.
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