Mitral Leaflet Adaptation to Ventricular Remodeling | Zendy

Miguel Chaput | Zendy; Mark D. Handschumacher | Zendy; François Tournoux | Zendy; Lanqi Hua | Zendy; Jorge Guerrero | Zendy; Gus J. Vlahakes | Zendy; Robert A. Levine | Zendy

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Mitral Leaflet Adaptation to Ventricular Remodeling

Author(s) -

Miguel Chaput,

Mark D. Handschumacher,

François Tournoux,

Lanqi Hua,

Jorge Guerrero,

Gus J. Vlahakes,

Robert A. Levine

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.749440

Subject(s) - medicine , cardiology , leaflet (botany) , functional mitral regurgitation , dilated cardiomyopathy , mitral regurgitation , mitral valve , cardiomyopathy , papillary muscle , anatomy , heart failure , ejection fraction , paleontology , biology

Functional mitral regurgitation (MR) is caused by systolic traction on the mitral leaflets related to ventricular distortion. Little is known about whether chronic tethering causes the mitral leaflet area to adapt to the geometric needs imposed by tethering, in part because of inability to reconstruct leaflet area in vivo. Our aim was to explore whether adaptive increases in leaflet area occur in patients with functional MR compared with normal subjects and to test the hypothesis that leaflet area influences MR severity.

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