Letter by Roldán et al Regarding Article, “Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass” | Zendy

Vanessa Roldán | Zendy; Francisco Marı́n | Zendy; Gregory Y.H. Lip | Zendy

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Letter by Roldán et al Regarding Article, “Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass”

Author(s) -

Vanessa Roldán,

Francisco Marı́n,

Gregory Y.H. Lip

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.746461

Subject(s) - medicine , atrial fibrillation , plasminogen activator , plasminogen activator inhibitor 1 , plasmin , cardiopulmonary bypass , fibrinolysis , tissue plasminogen activator , cardiology , enzyme , biochemistry , chemistry

To the Editor:Pretorius et al1 report that elevated plasminogen activator inhibitor-1 (PAI-1) levels are independent predictors of the development of atrial fibrillation (AF) after cardiopulmonary bypass, raising the possibility that postoperative AF is secondary to inflammation and fibrosis. PAI-1 also could promote myocardial remodeling by reducing matrix metalloproteinase activity because PAI-1 inhibits tissue plasminogen activator (tPA) and consequently plasmin, which is a potent activator of matrix metalloproteinases. There also is a link between fibrinolysis and inflammation, but …

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