Local Delivery of Gene Vectors From Bare-Metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-Stent Restenosis in Rat Carotid Arteries | Zendy

Ilia Fishbein | Zendy; Ivan S. Alferiev | Zendy; Marina Bakay | Zendy; Stanley J. Stachelek | Zendy; Peter Sobolewski | Zendy; Meizan Lai | Zendy; Hoon Choi | Zendy; IWei Chen | Zendy; Robert J. Levy | Zendy

Open Access

Local Delivery of Gene Vectors From Bare-Metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-Stent Restenosis in Rat Carotid Arteries

Author(s) -

Ilia Fishbein,

Ivan S. Alferiev,

Marina Bakay,

Stanley J. Stachelek,

Peter Sobolewski,

Meizan Lai,

Hoon Choi,

IWei Chen,

Robert J. Levy

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.746412

Subject(s) - restenosis , stent , medicine , genetic enhancement , gene delivery , bare metal stent , drug delivery , surgery , biochemistry , gene , nanotechnology , materials science , drug eluting stent , biology

Local drug delivery from polymer-coated stents has demonstrated efficacy for preventing in-stent restenosis; however, both the inflammatory effects of polymer coatings and concerns about late outcomes of drug-eluting stent use indicate the need to investigate innovative approaches, such as combining localized gene therapy with stent angioplasty. Thus, we investigated the hypothesis that adenoviral vectors (Ad) could be delivered from the bare-metal surfaces of stents with a synthetic complex for reversible vector binding.

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