Mutations in Sarcomere Protein Genes in Left Ventricular Noncompaction | Zendy

Sabine Klaassen | Zendy; Susanne Probst | Zendy; Erwin Oechslin | Zendy; Brenda Gerull | Zendy; Gregor Krings | Zendy; Pia Schuler | Zendy; Matthias Greutmann | Zendy; David Hürlimann | Zendy; M. Yegitbasi | Zendy; Lucía Pons | Zendy; Michael Gramlich | Zendy; JörgDetlef Drenckhahn | Zendy; Arnd Heuser | Zendy; Felix Berger | Zendy; Rolf Jenni | Zendy; Ludwig Thierfelder | Zendy

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Mutations in Sarcomere Protein Genes in Left Ventricular Noncompaction

Author(s) -

Sabine Klaassen,

Susanne Probst,

Erwin Oechslin,

Brenda Gerull,

Gregor Krings,

Pia Schuler,

Matthias Greutmann,

David Hürlimann,

M. Yegitbasi,

Lucía Pons,

Michael Gramlich,

JörgDetlef Drenckhahn,

Arnd Heuser,

Felix Berger,

Rolf Jenni,

Ludwig Thierfelder

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.746164

Subject(s) - myh7 , left ventricular noncompaction , sarcomere , proband , mutation , gene mutation , hypertrophic cardiomyopathy , genetics , medicine , cardiomyopathy , myh6 , gene , cardiology , biology , heart failure , myocyte , gene isoform

Left ventricular noncompaction constitutes a primary cardiomyopathy characterized by a severely thickened, 2-layered myocardium, numerous prominent trabeculations, and deep intertrabecular recesses. The genetic basis of this cardiomyopathy is still largely unresolved. We speculated that mutations in sarcomere protein genes known to cause hypertrophic cardiomyopathy and dilated cardiomyopathy may be associated with left ventricular noncompaction.

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