Open AccessRole of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury
Author(s) -
John W. Elrod,
Maddison D. Harrell,
Thomas P. Flagg,
Susheel Gundewar,
Mark A. Magnuson,
Colin G. Nichols,
William A. Coetzee,
David J. Lefer
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.745539
Subject(s) - sulfonylurea receptor , medicine , potassium channel , atp sensitive potassium channel , kir6.2 , sulfonylurea , ischemia , protein subunit , cardiology , inward rectifier potassium ion channel , pharmacology , reperfusion injury , glibenclamide , receptor , endocrinology , ion channel , biochemistry , biology , diabetes mellitus , insulin , gene
Opening of cardiac ATP-sensitive potassium channels (K(ATP) channels) is a well-characterized protective mechanism against ischemia and reperfusion injury. Evidence exists for an involvement of both sarcolemmal and mitochondrial K(ATP) channels in such protection. Classically, cardiac sarcolemmal K(ATP) channels are thought to be composed of Kir6.2 (inward-rectifier potassium channel 6.2) and SUR2A (sulfonylurea receptor type 2A) subunits; however, the evidence is strong that SUR1 (sulfonylurea receptor type 1) subunits are also expressed in the heart and that they may have a functional role. The aim of this study, therefore, was to examine the role of SUR1 in myocardial infarction.
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