Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice | Zendy

Christophe Combadière | Zendy; Stéphane Potteaux | Zendy; Mathieu P. Rodero | Zendy; Tabassome Simon | Zendy; Adeline Pézard | Zendy; Bruno Esposito | Zendy; Régine Merval | Zendy; Amanda E. I. Proudfoot | Zendy; Alain Tedgui | Zendy; Ziad Mallat | Zendy

Open Access

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C ^hi and Ly6C ^lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

Author(s) -

Christophe Combadière,

Stéphane Potteaux,

Mathieu P. Rodero,

Tabassome Simon,

Adeline Pézard,

Bruno Esposito,

Régine Merval,

Amanda E. I. Proudfoot,

Alain Tedgui,

Ziad Mallat

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.745091

Subject(s) - monocytosis , medicine , monocyte , cx3cr1 , ccr2 , chemokine , bone marrow , immunology , chemokine receptor , ccl2 , myeloid , macrophage , inflammation , biology , biochemistry , in vitro

Monocytes are critical mediators of atherogenesis. Deletion of individual chemokines or chemokine receptors leads to significant but only partial inhibition of lesion development, whereas deficiency in other signals such as CXCL16 or CCR1 accelerates atherosclerosis. Evidence that particular chemokine pathways may cooperate to promote monocyte accumulation into inflamed tissues, particularly atherosclerotic arteries, is still lacking.

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