Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo | Zendy

Michael D. Seddon | Zendy; Phil Chowienczyk | Zendy; Sally Brett | Zendy; Barbara Casadei | Zendy; Ajay M. Shah | Zendy

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Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo

Author(s) -

Michael D. Seddon,

Phil Chowienczyk,

Sally Brett,

Barbara Casadei,

Ajay M. Shah

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.744540

Subject(s) - vasodilation , endocrinology , medicine , nitric oxide synthase , enos , omega n methylarginine , nitric oxide , nitric oxide synthase type iii , endothelium , acetylcholine , arginine , endothelium derived relaxing factor , basal (medicine) , biology , biochemistry , amino acid , insulin

Nitric oxide (NO) has a pivotal role in the regulation of vascular tone and blood flow, with dysfunctional release contributing to disease pathophysiology. These effects have been attributed to NO production by the endothelial NO synthase (eNOS); however, recent evidence suggests that a neuronal NO synthase (nNOS) may also be expressed in arterial vessels.

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