Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells | Zendy

Zhonglin Xie | Zendy; Yunzhou Dong | Zendy; Roland W. Scholz | Zendy; Dietbert Neumann | Zendy; Ming-Hui Zou | Zendy

Open Access

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

Author(s) -

Zhonglin Xie,

Yunzhou Dong,

Roland W. Scholz,

Dietbert Neumann,

Ming-Hui Zou

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.744490

Subject(s) - ampk , metformin , amp activated protein kinase , protein kinase a , phosphorylation , protein kinase c , kinase , microbiology and biotechnology , medicine , endocrinology , biology , diabetes mellitus

Metformin, one of most commonly used antidiabetes drugs, is reported to exert its therapeutic effects by activating AMP-activated protein kinase (AMPK); however, the mechanism by which metformin activates AMPK is poorly defined. The objective of the present study was to determine how metformin activates AMPK in endothelial cells.

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