Noncanonical Wnt11 Signaling Is Sufficient to Induce Cardiomyogenic Differentiation in Unfractionated Bone Marrow Mononuclear Cells | Zendy

Michael P. Flaherty | Zendy; Ahmed AbdelLatif | Zendy; Qianhong Li | Zendy; Greg Hunt | Zendy; Smita Ranjan | Zendy; Qinghu Ou | Zendy; XianLiang Tang | Zendy; Robin K. Johnson | Zendy; Roberto Bolli | Zendy; Buddhadeb Dawn | Zendy

Open Access

Noncanonical Wnt11 Signaling Is Sufficient to Induce Cardiomyogenic Differentiation in Unfractionated Bone Marrow Mononuclear Cells

Author(s) -

Michael P. Flaherty,

Ahmed AbdelLatif,

Qianhong Li,

Greg Hunt,

Smita Ranjan,

Qinghu Ou,

XianLiang Tang,

Robin K. Johnson,

Roberto Bolli,

Buddhadeb Dawn

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.741066

Subject(s) - homeobox protein nanog , wnt signaling pathway , medicine , microbiology and biotechnology , bone marrow , cellular differentiation , peripheral blood mononuclear cell , wnt3a , cancer research , immunology , biology , signal transduction , embryonic stem cell , induced pluripotent stem cell , in vitro , biochemistry , gene

Despite the frequent clinical use of adult unfractionated bone marrow mononuclear cells (BMMNCs) for cardiac repair, whether these cells are capable of undergoing cardiomyogenic differentiation in vitro remains uncertain. In addition, the role of Wnt signaling in cardiomyogenic differentiation of adult cells is unclear.

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