Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin | Zendy

An L. Moens | Zendy; Eiki Takimoto | Zendy; Carlo G. Tocchetti | Zendy; Khalid Chakir | Zendy; Djahida Bedja | Zendy; Gianfranco Cormaci | Zendy; Elizabeth Ketner | Zendy; Maulik D. Majmudar | Zendy; Kathleen Gabrielson | Zendy; Marc K. Halushka | Zendy; James B. Mitchell | Zendy; Shyam Biswal | Zendy; Keith M. Chan | Zendy; Michael S. Wolin | Zendy; Nicholas J. C. King | Zendy; Nazareno Paolocci | Zendy; Hunter C. Champion | Zendy; David A. Kass | Zendy

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Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin

Author(s) -

An L. Moens,

Eiki Takimoto,

Carlo G. Tocchetti,

Khalid Chakir,

Djahida Bedja,

Gianfranco Cormaci,

Elizabeth Ketner,

Maulik D. Majmudar,

Kathleen Gabrielson,

Marc K. Halushka,

James B. Mitchell,

Shyam Biswal,

Keith M. Chan,

Michael S. Wolin,

Nicholas J. C. King,

Nazareno Paolocci,

Hunter C. Champion,

David A. Kass

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.737031

Subject(s) - pressure overload , tetrahydrobiopterin , muscle hypertrophy , medicine , fibrosis , endocrinology , oxidative stress , nitric oxide synthase , concentric hypertrophy , myocyte , diastole , cardiology , nitric oxide , blood pressure , cardiac hypertrophy

Sustained pressure overload induces pathological cardiac hypertrophy and dysfunction. Oxidative stress linked to nitric oxide synthase (NOS) uncoupling may play an important role. We tested whether tetrahydrobiopterin (BH4) can recouple NOS and reverse preestablished advanced hypertrophy, fibrosis, and dysfunction.

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