A Quantitative Trait Locus (LSq-1) on Mouse Chromosome 7 Is Linked to the Absence of Tissue Loss After Surgical Hindlimb Ischemia | Zendy

Ayotunde O. Dokun | Zendy; Sehoon Keum | Zendy; Surovi Hazarika | Zendy; Yongjun Li | Zendy; Gregory LaMonte | Zendy; Ferrin C. Wheeler | Zendy; Douglas A. Marchuk | Zendy; Brian H. Annex | Zendy

Open Access

A Quantitative Trait Locus (LSq-1) on Mouse Chromosome 7 Is Linked to the Absence of Tissue Loss After Surgical Hindlimb Ischemia

Author(s) -

Ayotunde O. Dokun,

Sehoon Keum,

Surovi Hazarika,

Yongjun Li,

Gregory LaMonte,

Ferrin C. Wheeler,

Douglas A. Marchuk,

Brian H. Annex

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.736447

Subject(s) - ischemia , claudication , medicine , hindlimb , quantitative trait locus , locus (genetics) , perfusion , intermittent claudication , pathology , amputation , genetics , biology , vascular disease , surgery , gene , arterial disease

Peripheral arterial disease (PAD) caused by occlusive atherosclerosis of the lower extremity has 2 major clinical manifestations. Critical limb ischemia is characterized by rest pain and/or tissue loss and has a > or = 40% risk of death and major amputation. Intermittent claudication causes pain on walking, has no tissue loss, and has amputation plus mortality rates of 2% to 4% per year. Progression from claudication to limb ischemia is infrequent. Risk factors in most PAD patients overlap. Thus, we hypothesized that genetic variations may be linked to presence or absence of tissue loss in PAD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research