Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart | Zendy

Takeshi Tokudome | Zendy; Ichiro Kishimoto | Zendy; Takeshi Horio | Zendy; Yuji Arai | Zendy; Daryl O. Schwenke | Zendy; Jun Hino | Zendy; Ichiro Okano | Zendy; Yuhei Kawano | Zendy; Masakazu Kohno | Zendy; Mikiya Miyazato | Zendy; Kazuwa Nakao | Zendy; Kenji Kangawa | Zendy

Open Access

Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart

Author(s) -

Takeshi Tokudome,

Ichiro Kishimoto,

Takeshi Horio,

Yuji Arai,

Daryl O. Schwenke,

Jun Hino,

Ichiro Okano,

Yuhei Kawano,

Masakazu Kohno,

Mikiya Miyazato,

Kazuwa Nakao,

Kenji Kangawa

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.732990

Subject(s) - atrial natriuretic peptide , medicine , endocrinology , natriuretic peptide , regulator of g protein signaling , phosphorylation , cyclic guanosine monophosphate , protein kinase a , biology , g protein , receptor , heart failure , microbiology and biotechnology , nitric oxide , gtpase activating protein

Mice lacking guanylyl cyclase-A (GC-A), a natriuretic peptide receptor, have pressure-independent cardiac hypertrophy. However, the mechanism underlying GC-A-mediated inhibition of cardiac hypertrophy remains to be elucidated. In the present report, we examined the role of regulator of G-protein signaling subtype 4 (RGS4), a GTPase activating protein for G(q) and G(i), in the antihypertrophic effects of GC-A.

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