Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor–Mediated Relaxation | Zendy

Julie Saliez | Zendy; Caroline Bouzin | Zendy; Gayatri Rath | Zendy; Philippe Ghisdal | Zendy; Fanny Desjardins | Zendy; Rita Rezzani | Zendy; Luigi Fabrizio Rodella | Zendy; Joris Vriens | Zendy; B. Nilius | Zendy; Olivier Féron | Zendy; JeanLuc Balligand | Zendy; Chantal Dessy | Zendy

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Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor–Mediated Relaxation

Author(s) -

Julie Saliez,

Caroline Bouzin,

Gayatri Rath,

Philippe Ghisdal,

Fanny Desjardins,

Rita Rezzani,

Luigi Fabrizio Rodella,

Joris Vriens,

B. Nilius,

Olivier Féron,

JeanLuc Balligand,

Chantal Dessy

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.731679

Subject(s) - medicine , endothelium derived hyperpolarizing factor , endothelium , relaxation (psychology) , neuroscience , microbiology and biotechnology , nitric oxide , biology , charybdotoxin

In endothelial cells, caveolin-1, the structural protein of caveolae, acts as a scaffolding protein to cluster lipids and signaling molecules within caveolae and, in some instances, regulates the activity of proteins targeted to caveolae. Specifically, different putative mediators of the endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation are located in caveolae and/or regulated by the structural protein caveolin-1, such as potassium channels, calcium regulatory proteins, and connexin 43, a molecular component of gap junctions.

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