Microsomal Prostaglandin E Synthase-1 Deletion Suppresses Oxidative Stress and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation | Zendy

Miao Wang | Zendy; Eric Lee | Zendy; WenLiang Song | Zendy; Emanuela Ricciotti | Zendy; Daniel J. Rader | Zendy; John A. Lawson | Zendy; Ellen Puré | Zendy; Garret A. FitzGerald | Zendy

Open Access

Microsomal Prostaglandin E Synthase-1 Deletion Suppresses Oxidative Stress and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

Author(s) -

Miao Wang,

Eric Lee,

WenLiang Song,

Emanuela Ricciotti,

Daniel J. Rader,

John A. Lawson,

Ellen Puré,

Garret A. FitzGerald

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.731398

Subject(s) - medicine , abdominal aortic aneurysm , oxidative stress , angiotensin ii , prostaglandin , atp synthase , endocrinology , angiotensin 1 , aortic aneurysm , renin–angiotensin system , cardiology , aneurysm , enzyme , aorta , biochemistry , surgery , receptor , blood pressure , biology

Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes isomerization of the cyclooxygenase product PGH(2) into PGE(2). Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis. The role of mPGES-1 in abdominal aortic aneurysm is unknown.

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