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To the Editor:We read with interest the recent study by Aarnoudse et al,1 which provides convincing evidence for an association between 2 common single-nucleotide polymorphisms in the neuronal nitric oxide synthase (nNOS/NOS-1) activator protein gene and prolongation of the heart rate–adjusted QT interval on ECGs from subjects in the Rotterdam study. This study builds on the findings of a recent genome-wide association study showing a similar link.2 These results are both surprising and clinically relevant, as it is not immediately …

Letter by Herring and Paterson Regarding Article, “Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study”