Open AccessInhaled Nitric Oxide Enables Artificial Blood Transfusion Without Hypertension
Author(s) -
Binglan Yu,
Michael J. Raher,
Gian Paolo Volpato,
Kenneth D. Bloch,
Fumito Ichinose,
Warren M. Zapol
Publication year - 2008
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.107.729137
Subject(s) - medicine , vasoconstriction , hemoglobin , methemoglobin , nitric oxide , hypoxic pulmonary vasoconstriction , anesthesia , methemoglobinemia , pulmonary hypertension , pharmacology , systemic administration , nitric oxide synthase , biology , microbiology and biotechnology , in vivo
One of the major obstacles hindering the clinical development of a cell-free, hemoglobin-based oxygen carrier (HBOC) is systemic vasoconstriction.
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