Complementary Roles for Biomarkers of Biomechanical Strain ST2 and N-Terminal Prohormone B-Type Natriuretic Peptide in Patients With ST-Elevation Myocardial Infarction | Zendy

Marc S. Sabatine | Zendy; David A. Morrow | Zendy; Luke Higgins | Zendy; Catherine MacGillivray | Zendy; Wei Guo | Zendy; C Bode | Zendy; Nader Rifai | Zendy; Christopher P. Can | Zendy; Robert E. Gerszten | Zendy; Richard Lee | Zendy

Open Access

Complementary Roles for Biomarkers of Biomechanical Strain ST2 and N-Terminal Prohormone B-Type Natriuretic Peptide in Patients With ST-Elevation Myocardial Infarction

Author(s) -

Marc S. Sabatine,

David A. Morrow,

Luke Higgins,

Catherine MacGillivray,

Wei Guo,

C Bode,

Nader Rifai,

Christopher P. Can,

Robert E. Gerszten,

Richard Lee

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.728022

Subject(s) - medicine , prohormone , natriuretic peptide , myocardial infarction , cardiology , strain (injury) , heart failure , endocrinology , hormone

ST2 is a member of the interleukin-1 receptor family with a soluble form that is markedly upregulated on application of biomechanical strain to cardiac myocytes. Circulating ST2 levels are elevated in the setting of acute myocardial infarction, but the predictive value of ST2 independent of traditional clinical factors and of an established biomarker of biomechanical strain, N-terminal prohormone B-type natriuretic peptide (NT-proBNP), has not been established.

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