Smooth Muscle Cells Healing Atherosclerotic Plaque Disruptions Are of Local, Not Blood, Origin in Apolipoprotein E Knockout Mice | Zendy

Jacob Fog Bentzon | Zendy; Claus S. Søndergaard | Zendy; Moustapha Kassem | Zendy; Erling Falk | Zendy

Open Access

Smooth Muscle Cells Healing Atherosclerotic Plaque Disruptions Are of Local, Not Blood, Origin in Apolipoprotein E Knockout Mice

Author(s) -

Jacob Fog Bentzon,

Claus S. Søndergaard,

Moustapha Kassem,

Erling Falk

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.722355

Subject(s) - apolipoprotein e , medicine , bone marrow , pathology , fibrous cap , wound healing , knockout mouse , genetically modified mouse , progenitor cell , bone healing , apolipoprotein b , transgene , stem cell , anatomy , microbiology and biotechnology , biology , immunology , endocrinology , receptor , cholesterol , biochemistry , disease , gene

Signs of preceding episodes of plaque rupture and smooth muscle cell (SMC)-mediated healing are common in atherosclerotic plaques, but the source of the healing SMCs is unknown. Recent studies suggest that activated platelets adhering to sites of injury recruit neointimal SMCs from circulating bone marrow-derived progenitor cells. Here, we analyzed the contribution of this mechanism to plaque healing after spontaneous and mechanical plaque disruption in apolipoprotein E knockout (apoE-/-) mice.

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