Aldosterone-Induced Coronary Dysfunction in Transgenic Mice Involves the Calcium-Activated Potassium (BKCa) Channels of Vascular Smooth Muscle Cells | Zendy

Marie-Lory Ambroisine | Zendy; Julie Favre | Zendy; Patricia Oliviéro | Zendy; Camille Rodriguez | Zendy; Ji Gao | Zendy; Christian Thuillez | Zendy; JaneLise Samuel | Zendy; Vincent Richard | Zendy; Claude Delcayre | Zendy

Open Access

Aldosterone-Induced Coronary Dysfunction in Transgenic Mice Involves the Calcium-Activated Potassium (BKCa) Channels of Vascular Smooth Muscle Cells

Author(s) -

Marie-Lory Ambroisine,

Julie Favre,

Patricia Oliviéro,

Camille Rodriguez,

Ji Gao,

Christian Thuillez,

JaneLise Samuel,

Vincent Richard,

Claude Delcayre

Publication year - 2007

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.722009

Subject(s) - iberiotoxin , medicine , endocrinology , apamin , aldosterone , myograph , charybdotoxin , vascular smooth muscle , aldosterone synthase , acetylcholine , potassium channel , vasodilation , chemistry , renin–angiotensin system , blood pressure , smooth muscle

Cardiomyocyte-specific overexpression of aldosterone synthase in male (MAS) mice induces a nitric oxide-independent coronary dysfunction. Because calcium-activated potassium (BKCa) channels are essential for vascular smooth muscle cell (VSMC) relaxation, we hypothesized that aldosterone alters their expression and/or function in VSMCs.

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