Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts | Zendy

Takeshi Yamamoto | Zendy; Masafumi Yano | Zendy; Xiaojuan Xu | Zendy; Hitoshi Uchinoumi | Zendy; Hiroki Tateishi | Zendy; Mamoru Mochizuki | Zendy; Tetsuro Oda | Zendy; Shigeki Kobayashi | Zendy; Noriaki Ikemoto | Zendy; Masunori Matsuzaki | Zendy

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Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts

Author(s) -

Takeshi Yamamoto,

Masafumi Yano,

Xiaojuan Xu,

Hitoshi Uchinoumi,

Hiroki Tateishi,

Mamoru Mochizuki,

Tetsuro Oda,

Shigeki Kobayashi,

Noriaki Ikemoto,

Masunori Matsuzaki

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.718957

Subject(s) - ryanodine receptor 2 , ryanodine receptor , biophysics , receptor , endoplasmic reticulum , medicine , microbiology and biotechnology , endocrinology , biochemistry , chemistry , biology

We previously demonstrated that defective interdomain interaction between N-terminal (0 to 600) and central regions (2000 to 2500) of ryanodine receptor 2 (RyR2) induces Ca2+ leak in failing hearts and that K201 (JTV519) inhibits the Ca2+ leak by correcting the defective interdomain interaction. In the present report, we identified the K201-binding domain and characterized the role of this novel domain in the regulation of the RyR2 channel.

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