Endothelial Dysfunction and Cytomegalovirus Replication in Pediatric Heart Transplantation | Zendy

Jacob Simmonds | Zendy; Matthew J. Fenton | Zendy; Catherine Dewar | Zendy; Elizabeth A. Ellins | Zendy; Clare Storry | Zendy; David Cubitt | Zendy; John Deanfield | Zendy; Nigel Klein | Zendy; Julian Halcox | Zendy; Michael Burch | Zendy

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Endothelial Dysfunction and Cytomegalovirus Replication in Pediatric Heart Transplantation

Author(s) -

Jacob Simmonds,

Matthew J. Fenton,

Catherine Dewar,

Elizabeth A. Ellins,

Clare Storry,

David Cubitt,

John Deanfield,

Nigel Klein,

Julian Halcox,

Michael Burch

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.718874

Subject(s) - medicine , transplantation , viremia , human cytomegalovirus , endothelial dysfunction , cardiology , brachial artery , cytomegalovirus , heart transplantation , immunology , viral disease , blood pressure , herpesviridae , human immunodeficiency virus (hiv) , virus

Cardiac allograft vasculopathy is the major limiting factor to the long-term success of pediatric heart transplantation. Cytomegalovirus (CMV) has been shown to be a significant risk factor for the development of cardiac allograft vasculopathy. Recent work has demonstrated CMV DNA in leukocytes in the absence of direct allograft infection, suggesting that vascular changes may not be limited to the allograft.

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