Technetium 99m–Labeled Annexin V Scintigraphy of Platelet Activation in Vegetations of Experimental Endocarditis | Zendy

François Rouzet | Zendy; Miguel Dominguez Hernandez | Zendy; Florence Hervatin | Zendy; Laure SardaMantel | Zendy; A. Lefort | Zendy; Xavier Duval | Zendy; Liliane Louedec | Zendy; B. Fantin | Zendy; Dominique Le Guludec | Zendy; JeanBaptiste Michel | Zendy

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Technetium 99m–Labeled Annexin V Scintigraphy of Platelet Activation in Vegetations of Experimental Endocarditis

Author(s) -

François Rouzet,

Miguel Dominguez Hernandez,

Florence Hervatin,

Laure SardaMantel,

A. Lefort,

Xavier Duval,

Liliane Louedec,

B. Fantin,

Dominique Le Guludec,

JeanBaptiste Michel

Publication year - 2008

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.107.718114

Subject(s) - medicine , endocarditis , scintigraphy , technetium 99m , technetium , platelet , nuclear medicine , radionuclide imaging

The pathophysiology of infective endocarditis involves a pathogen/host tissue interaction, leading to formation of infected thrombotic vegetations. Annexin V is a ligand of phosphatidylserines exposed by activated platelets and apoptotic cells. Because vegetations are platelet-fibrin clots in which platelet proaggregant activity is enhanced by bacterial colonization, we investigated the ability of annexin V labeled with technetium Tc 99m (99mTc-ANX) to provide functional imaging of these vegetations in experimental models of infective endocarditis. This ability was assessed in rabbits and rats because of the different interest of these 2 species in preclinical analysis.

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